Development of a five degree-of-freedom biomanipulator for autonomous single cell electroporation
Bibliographic record
Abstract
Studies of individual cells via microscopy and microinjection are a key component in research on gene functions, cancer, stem cells, and reproductive technology. As biomedical experiments become more complex, there is an urgent need for robotic systems to: improve cell manipulation, increase throughput, reduce lost cells, and improve reaction detection. Automation of these tasks using visual servoing creates significant benefits for biomedical laboratories including repeatability of experiments, higher throughput, and a controlled environment capable of operating 24 hours a day. In this work the design and development of a new five degree-of- freedom biomanipulator designed for single-cell microinjection, is described. The biomanipulator employs three degrees of linear motion and two degrees of rotation. This provides the ability to manipulate/micro-inject cells at varying orientations, thereby increasing flexibility in dealing with complex operations such as injecting clustered cells. The capability of the biomanipulator is shown with preliminary experimental results using mouse myeloma cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".