Olanzapine led to fewer withdrawals than other antipsychotic drugs but increased weight gain, glucose, and lipids
Bibliographic record
Abstract
Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209–23. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In patients with chronic schizophrenia, are atypical antipsychotic drugs more effective than a conventional antipsychotic? Clinical impact ratings GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★★☆ ### ![Graphic][5] Design: randomised controlled trial (Clinical Antipsychotic Trials of Intervention Effectiveness [CATIE]). ### ![Graphic][6] Allocation: unclear.* ### ![Graphic][7] Blinding: blinded (clinicians and patients).* ### ![Graphic][8] Follow up period: up to 18 months. ### ![Graphic][9] Setting: 16 university clinics, 10 state mental health agencies, 7 Veterans Affairs medical centres, 6 private non-profit agencies, 4 private practice sites, and 14 mixed system sites in the US. ### ![Graphic][10] Patients: 1493 patients 18–65 years of age (mean age 41 y, 74% men, 60% white) who were diagnosed with schizophrenia beyond a first episode and able to take oral antipsychotic medication. Exclusion criteria included schizoaffective disorder or other cognitive disorders, serious and unstable medical conditions, contraindications to study drugs, … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.volume%253D353%26rft.issue%253D12%26rft.spage%253D1209%26rft.epage%253D1223%26rft.atitle%253DEffectiveness%2Bof%2Bantipsychotic%2Bdrugs%2Bin%2Bpatients%2Bwith%2Bchronic%2Bschizophrenia.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa051688%26rft_id%253Dinfo%253Apmid%252F16172203%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa051688&link_type=DOI [3]: /lookup/external-ref?access_num=16172203&link_type=MED&atom=%2Febmed%2F11%2F3%2F81.atom [4]: /lookup/external-ref?access_num=000232000400005&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Editorial About the Canadian research system: no · About a Canadian topic: no | Observational | medium |
| gpt | no category Domain: not available · Genre: Commentary About the Canadian research system: no · About a Canadian topic: no | Not applicable | high |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.010 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".