An immunohistochemical studyon the regulation of estrogen receptor ? by estradiolin the endometrium of the immature ewe
Bibliographic record
Abstract
The effects of estradiol-17β (E2) on the expression of estrogen receptor α (ERα) in stromal and epithelial cells of endometrium in prepubertal lambs were investigated.Twenty threemonth-old lambs were treated or not treated with one, two or three i.m. injections of E2 (1 µg .kg -1 ) in corn oil at intervals of 24 h.Lambs were slaughtered 12 or 24 h after the last injection.An immunohistochemical technique was used to visualize ERα immunostaining which was then analyzed quantitatively by a computer imaging analysis system.Seven endometrial compartments defined by cell type and location were analyzed separately.Positive staining of ERα was seen in the nuclei of stromal and epithelial cells.Glandular epithelium located next to the myometrium was stained more intensely than that next to the luminal epithelium and this phenomenon was maintained during treatment.Significantly less immunostaining was found in stromal cells 12 and 24 h after the first injection compared to the control group.A similar pattern was found in the glandular epithelium, although the decrease was more pronounced and the restoration of ERα was faster.This study shows that E2 treatment down regulates ERα in the endometrium temporarily in both stromal and epithelial cells, but the characteristics of this effect seems to be cell type specific. estrogen / receptor / uterus / lamb / immunohistochemistryRésumé -Étude immuno-cytologique de la régulation du récepteur aux œstrogènes ERα par l'œstradiol dans l'endomètre de la brebis impubère.Les effets de l'œstradiol-17β (E2) ont été étudiés sur l'expression du récepteur aux œstrogènes ERα dans les cellules du stroma et de l'épithélium de l'endomètre chez la brebis impubère.Vingt agnelles âgées de 3 mois ont reçu ou non une, deux ou
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".