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Record W2145163654 · doi:10.1101/sqb.2009.74.002

Eradicating Typological Thinking in Prokaryotic Systematics and Evolution

2009· review· en· W2145163654 on OpenAlexafffund
W. Ford Doolittle

Bibliographic record

VenueCold Spring Harbor Symposia on Quantitative Biology · 2009
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Phylogenetic Studies
Canadian institutionsDalhousie University
FundersCanadian Institutes of Health Research
KeywordsTree of life (biology)ProkaryotePopulationEvolutionary biologyBiologyMetagenomicsValue (mathematics)SystematicsAntithesisEpistemologyEcologyPhylogeneticsPhilosophySociologyGeneticsComputer scienceTaxonomy (biology)DemographyGene

Abstract

fetched live from OpenAlex

In 1982, John Maynard Smith called for an evolutionary "New Synthesis" specific for prokaryotes, observing that "population thinking has been well developed for fully half a century, but has yet to be adopted by microbiology" (Maynard Smith 1982). Twenty-seven years later, typological thinking (population thinking's antithesis) still dominates the field. Evidence for this includes the continuing debates on the reality of prokaryotic species, the value of the term "prokaryote," and the significance of the tree of life (TOL). In each case, the unexpected prevalence of interlineage transfer of genetic information has been (or should now be) the catalyst for the final Darwinization of our discipline. With examples from phylogenomics, I argue that "species," "domains," and the "TOL" are reifications that we can do without, especially as genomics dissolves into metagenomics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0040.004
Science and technology studies0.0010.008
Scholarly communication0.0030.008
Open science0.0010.002
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0030.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.319
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations31
Published2009
Admission routes2
Has abstractyes

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