Inflammatory Arthritis in a Patient with Primary Biliary Cirrhosis: B Cell Mediated Synovitis
Bibliographic record
Abstract
To the Editor: Primary biliary cirrhosis (PBC) is a chronic cholestatic autoimmune liver disease of unknown etiology, associated with the presence of antimitochondrial antibodies in 95% of patients1–6. Prevalence of this condition is estimated at between 20 and 240 cases per million population, the most frequent symptoms being fatigue, jaundice, and pruritis. Arthritis is reported in 4%–42% of patients with PBC in several series1–3. Some patients develop a symmetrical erosive small-joint arthritis, often in association with a positive rheumatoid factor (RF), that is indistinguishable from rheumatoid arthritis (RA). There is an increased incidence of RA, Sjögren’s syndrome, Raynaud’s phenomenon, and hypothyroidism in patients with PBC7. Up to 31% of patients, however, develop an asymmetric, nondeforming arthritis that seems unique to PBC7. However, there have been reports of PBC patients developing a deforming and/or erosive arthritis3,4, … Address correspondence to Dr. Smith; E-mail: malcolm.smith{at}health.sa.gov.au
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.009 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.001 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.015 | 0.009 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".