Temozolomide for Anaplastic Astrocytoma: A Case Report of Aplastic Anemia, Sustained Treatment Response, and Spontaneous Marrow Recovery
Bibliographic record
Abstract
12.00 Introduction: Temozolomide is an alkylating agent used in the treatment of high-grade glioma. Rarely, it can induce an aplastic anemia that is usually rapidly fatal if the patient is unable to undergo a bone marrow transplant. This is the first case report of a temozolomide-induced aplastic anemia in an anaplastic astrocyoma patient, and of spontaneous complete marrow recovery with supportive care. Presentation of Case: 21 year old Caucasian female presented with pancytopenia after 39 days of temozolomide at 75mg/m 2 /day concurrent with radiation. Hematologic nadir occurred and aplastic anemia was diagnosed 3 months after the first dose of temzolomide. She required multiple platelet and red cell transfusions in addition to granulocyte colony stimulating factor therapy. During this time, the patient also became pregnant and delivered a healthy baby. With supportive care, the patient's white cell count recovered after 6 months, red cell count after 1.5 years, and platelets after 3 years. Her tumour remains stable more than 4 years after temozolomide and radiation with no further treatment. Conclusions: Aplastic anemia may occur with low-dose temozolomide. Spontaneous marrow recovery using only supportive care is possible following temozolomide-induced aplastic anemia . Normal 0 7.8 磅 0 2 false false false EN-US ZH-CN X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:普通表格; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.5pt; mso-bidi-font-size:11.0pt; font-family:Calibri,sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:宋体; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Times New Roman; mso-bidi-theme-font:minor-bidi; mso-font-kerning:1.0pt;}
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".