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All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

2014· article· en· 825 citations· W2145909957 on OpenAlex· 10.1038/nmeth.3000

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.054
GPT teacher head0.416
Teacher spread
0.362 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Methods
Topic
Photoreceptor and optogenetics research
Field
Neuroscience
Canadian institutions
University of Alberta
Funders
Division of Chemical, Bioengineering, Environmental, and Transport SystemsNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNatural Sciences and Engineering Research Council of CanadaNational Science FoundationCanadian Institutes of Health ResearchMcGovern Institute for Brain Research, Massachusetts Institute of TechnologyAlberta InnovatesDivision of Emerging Frontiers in Research and InnovationNew York Stem Cell FoundationMassachusetts Institute of TechnologyUniversity of AlbertaDefense Advanced Research Projects AgencyNational Institute of Biomedical Imaging and BioengineeringSkolkovo Institute of Science and TechnologyNational Institute on Deafness and Other Communication DisordersNational Institute on Drug AbuseAlberta Innovates - Technology FuturesNational Institutes of Health
Keywords
ChannelrhodopsinElectrophysiologyVoltage-sensitive dyeOptogeneticsMicrosecondBiophysicsNeuroscienceBiologyPhysicsOptics
Has abstract in OpenAlex
no