Acebutolol and Immediate Release Melatonin in Treatment of Smith-Magenis Syndrome
Bibliographic record
Abstract
Sleep disturbance occurs in Smith-Magenis syndrome (SMS) as part of the phenotype. It appears that this disturbance lies primarily in an inversion of the circadian rhythm of melatonin. We assessed whether the use of melatonin and acebutolol together would benefit a patient with SMS with regard to sleep and behavior. Our patient entered a four-way crossover, double-blind, double dummy, placebo-controlled n-of-1 trial, using immediate release melatonin, acebutolol and placebo. The duration of the study was 24 consecutive nights. The primary outcome measure was total nocturnal sleep. Placebo/placebo showed the longest total duration of sleep, 10.62 hours (95% CI: 9.88 - 11.36) as compared to melatonin and acebutolol together with 10.25 (95% CI: 9.40 - 11.11). There were no significant differences found between the secondary outcome measures in particular behavior or global satisfaction. Our results suggest there is no benefit to sleep or subsequent behavior from adding acebutolol and/or immediate release melatonin in patients with SMS. J Med Cases. 2015;6(4):176-178 doi: http://dx.doi.org/10.14740/jmc2102w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".