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Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine

2008· review· en· 1,140 citations· W2147163301 on OpenAlex· 10.1146/annurev.anchem.1.031207.112754

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Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free imaging technique that is capable of real-time, nonperturbative examination of living cells and organisms based on molecular vibrational spectroscopy. Recent advances in detection schemes, understanding of contrast mechanisms, and developments of laser sources have enabled superb sensitivity and high time resolution. Emerging applications, such as metabolite and drug imaging and tumor identification, raise many exciting new possibilities for biology and medicine.

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The record

Venue
Annual Review of Analytical Chemistry
Topic
Spectroscopy Techniques in Biomedical and Chemical Research
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
National Institute of General Medical SciencesUniversity of OttawaMassachusetts General HospitalNational Institutes of HealthPfizer
Keywords
Raman scatteringMicroscopyRaman spectroscopyNanotechnologyCoherent anti-Stokes Raman spectroscopyMaterials scienceOpticsPhysics
Has abstract in OpenAlex
yes