Complexe majeur d’histocompatibilité de classe II : diversité fonctionnelle
Bibliographic record
Abstract
Hormis leurs rôles cruciaux dans la présentation antigénique aux lymphocytes T CD4+ et dans la susceptibilité de l’organisme aux maladies autoimmunes, les molécules du complexe majeur d’histocompatibilité (CMH) de classe II ont la particularité d’être capables de transmettre des signaux à travers la membrane cellulaire. Ces signaux retentissent sur les diverses fonctions biologiques de ces molécules. Paradoxalement, les domaines cytoplasmiques et transmembranaires de ces molécules sont dépourvus des motifs classiques de signalisation. La mise en évidence des molécules du CMH de classe II, dans les microdomaines membranaires appelés radeaux lipidiques, enrichis en kinases et molécules adaptatrices, pourrait contribuer à élucider les mécanismes par lesquels les molécules du CMH de classe II transmettent leurs signaux.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".