Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
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- 0.232 · how far apart the two teachers sit on this one work
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Abstract
Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease.
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The record
- Venue
- The Journal of Experimental Medicine
- Topic
- T-cell and B-cell Immunology
- Field
- Immunology and Microbiology
- Canadian institutions
- —
- Funders
- National Institute of Allergy and Infectious DiseasesSchool of Medicine, New York UniversityNational Institute of General Medical SciencesNational Cancer InstituteNational Institutes of HealthDeutsche ForschungsgemeinschaftMultiple Sclerosis SocietyYork UniversityCrohn's and Colitis FoundationMemorial Sloan-Kettering Cancer CenterLeona M. and Harry B. Helmsley Charitable TrustCrohn's and Colitis Foundation of America
- Keywords
- Neuropilin 1FOXP3BiologyImmune systemImmunologyCell biologyCancer research
- Has abstract in OpenAlex
- yes