Preparation of [<sup>11</sup>C]methyl nona‐fluorobutyl‐1‐sulfonate ([<sup>11</sup>C]MeONf) and its use in the synthesis of [<sup>11</sup>C]‐6‐OH‐BTA‐1
Bibliographic record
Abstract
Abstract The rapid, simple and high‐yield synthesis of the extraordinarily reactive 11 C‐methylating agent, [ 11 C]methyl nona‐fluorobutyl‐1‐sulfonate ([ 11 C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, [ 11 C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, [ 11 C]MeONf seems to surpass [ 11 C]methyl trifluoromethansulfonate ([ 11 C]MeOTf) as a methylating agent in this particular case giving the 11 C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley & Sons, Ltd.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".