Paraconiothyrium sp. P83F4/1: antioxidant and antiproliferative activities of endophytic fungus associated with Rheedia brasiliensis plant
Bibliographic record
Abstract
The endophyte Paraconiothyrium sp. P83F4/1 was isolated from leaves of the Rheedia brasiliensis medicinal plant from a bioprospecting study. This is the first report of isolation of Paraconiothyrium in leaves of R. brasiliensis and the fermentation product obtained with this fungus in ethyl acetate was evaluated for their potential bioactive through antioxidant assay by DPPH (radical 1,1-diphenyl-2-picrylhydrazyl) method and antiproliferative assays in human tumoral cells using the sulphorhodamine B (SRB) technique for evaluating the cellular growth. The antioxidant assay, tested at 90 mg/mL, the fungal extract showed scavenging capacity of 58.92 %, being significant (p<0.05) compared the standard commercial butyl hydroxy toluene: 39.52 %. In the antiproliferative assay, the extract was selective on human keratinocyte cells (HaCat) with GI 50 0.95 mg/mL, whose mean log GI 50 = - 0.02, according to National Cancer Institute (NCI-USA) criteria, it makes a powerful extract. Cells HaCat are involved directly in diseases such as psoriasis. These results indicate the antioxidant and antiproliferative potentials of the crude extract of fermentation of the endophytic fungus Paraconiothyrium sp. P83F4/1 isolated from the leaves of R. brasiliensis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".