Plasma Disposition of Conventional and Long Acting Moxifloxacin in Sheep after Intramuscular Administration
Bibliographic record
Abstract
This study describes disposition of long acting moxifloxacin and conventional formulations of moxifloxacin in sheep after intramuscular administration in five male sheep. Long acting moxifloxacin solution (10% moxifloxacin in solution with L-arginine, N-butyl alcohol and benzyl alcohol) and conventional moxifloxacin (10%) were injected in deep gluteal muscle. Blood samples were collected from contra lateral jugular vein in test tubes containing 30~50 IU heparin (anticoagulant) periodically from 5 min to 96 h after drug administration. Drug concentrations in plasma were determined using High Performance Liquid Chromatography (HPLC) with Fluorescence Detector. The mobile phase consisted of a mixture of buffer (10 gm of tetrabutyl ammonium hydrogen sulphate per liter-deionised water) and acetonitrile (80: 20). The buffer was 0.067 M of disodium hydrogen phosphate with pH of 7.5. The flow rate was 1 mL/min at ambient temperature. The effluent was monitored at 296 nm excitation and 504 nm emissions wavelength. HPLC with Fluorescence Detector method for plasma moxifloxacin assay was standardized with specific modification for plasma of sheep in present study. After single dose intramuscular administration of long acting moxifloxacin the plasma concentration of (0.013±0.0005) µg/mL was maintained for up to 96 h. Conventional formulation of moxifloxacin remained in body for up to 36 h of drug administration with the level of (0.016±0.001) µg/mL.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".