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Record W2149665587 · doi:10.1038/ng.2261

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

2012· review· en· W2149665587 on OpenAlexaff
Patrick T. Ellinor, Kathryn L. Lunetta, Christine M. Albert, Nicole L. Glazer, Marylyn D. Ritchie, Albert V. Smith, Dan E. Arking, Martina Müller‐Nurasyid, Bouwe P. Krijthe, Steven A. Lubitz, Mina K. Chung, Marcus Dörr, Kouichi Ozaki, Jason D. Roberts, J. G. Smith, Arne Pfeufer, Moritz F. Sinner, Kurt Lohman, Jingzhong Ding, Nicholas L. Smith, Jonathan D. Smith, Michiel Rienstra, Kenneth Rice, David R. Van Wagoner, Jared W. Magnani, Reza Wakili, Sebastian Clauß, Jerome I. Rotter, Gerhard Steinbeck, Lenore J. Launer, R. W. Davies, Matthew Borkovich, Tamara B. Harris, Honghuang Lin, Uwe Völker, Henry Völzke, David J. Milan, Albert Hofman, Eric Boerwinkle, Lin Y. Chen, Elsayed Z. Soliman, Benjamin F. Voight, Li Guo, Aravinda Chakravarti, Michiaki Kubo, Usha B. Tedrow, Lynda M. Rose, Paul M. Ridker, David Conen, Tatsuhiko Tsunoda, Tetsushi Furukawa, Nona Sotoodehnia, Siyan Xu, Naoyuki Kamatani, Daniel Levy, Yusuke Nakamura, Babar Parvez, Saagar Mahida, Karen L. Furie, Jonathan Rosand, Raafia Muhammad, Bruce M. Psaty, Thomas Meitinger, Siegfried Perz, H‐Erich Wichmann, Jacqueline C.M. Witteman, W.H. Linda Kao, Sekar Kathiresan, Dan M. Roden, André G. Uitterlinden, Fernando Rivadeneira, Barbara McKnight, Marketa Sjögren, Anne B. Newman, Yongmei Liu, Michael H. Gollob, Olle Melander, Toshihiro Tanaka, Bruno H. Stricker, Stephan B. Felix, Álvaro Alonso, Dawood Darbar, John Barnard, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Vilmundur Guðnason, Stefan Kääb

Bibliographic record

VenueNature Genetics · 2012
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversity of Ottawa
FundersNational Center for Advancing Translational SciencesNational Institute on Drug AbuseNational Heart, Lung, and Blood Institute
KeywordsGenome-wide association studyAtrial fibrillationBiologyCandidate geneStroke (engine)Genetic associationGeneticsInternal medicineGeneBioinformaticsSingle-nucleotide polymorphismGenotypeMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.005
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0020.002
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.098
GPT teacher head0.382
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations609
Published2012
Admission routes1
Has abstractno

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