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Record W2149740262 · doi:10.1189/jlb.0712365

The role of circulating fibrocytes in inflammation and autoimmunity

2012· review· en· W2149740262 on OpenAlexaff
Carole L. Galligan, Eleanor N. Fish

Bibliographic record

VenueJournal of Leukocyte Biology · 2012
Typereview
Languageen
FieldMedicine
TopicInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Canadian institutionsUniversity of TorontoUniversity Health Network
Fundersnot available
KeywordsFibrocyteInflammationImmunologyAutoimmunityImmune systemBiologyChemokineMesenchymal stem cellCytokineCell biology

Abstract

fetched live from OpenAlex

Abstract Review on the role of circulating fibrocytes in augmenting the inflammatory/immune processes, and contributing to tissue remodeling in autoimmune diseases. Autoimmunity is a chronic process resulting in inflammation, tissue damage, and subsequent tissue remodeling. Circulating fibrocytes are bone marrow-derived cells with characteristics of hematopoietic and mesenchymal cells. These cells have been implicated in many inflammatory and fibrotic conditions as well as in wound healing. Fibrocytes can amplify the inflammatory/immune response through multiple mechanisms, including antigen presentation, cytokine and chemokine secretion, and production of MMPs. Increased numbers of circulating fibrocytes are observed in RA, systemic scleroderma, and Gravesˈ disease. Here, we review the current literature and potential involvement of fibrocytes in inflammation and autoimmunity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.995
Threshold uncertainty score0.366

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.325
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations60
Published2012
Admission routes1
Has abstractyes

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