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Record W2150796846 · doi:10.2217/fvl.12.112

Transcriptomics and Quantitative Proteomics in Virology

2012· article· en· W2150796846 on OpenAlexaff
Alicia R. Berard, Andrea Kroeker, Kevin M. Coombs

Bibliographic record

VenueFuture Virology · 2012
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicAnimal Virus Infections Studies
Canadian institutionsChildren's Hospital Research Institute of ManitobaUniversity of Manitoba
Fundersnot available
KeywordsBiologyProteomicsHost (biology)Computational biologyViral replicationVirusVirologyPathogenicityImmune systemTranscriptomeQuantitative proteomicsGeneGeneticsGene expressionMicrobiology

Abstract

fetched live from OpenAlex

Viral proteins and their roles in virus replication are typically well understood. However, their interactions with host proteins are currently not as well defined, and a better understanding may lead to novel findings involving virus replication, pathogenicity, host immune responses and antiviral therapies. With recent advances in 'omic' technologies, it is now possible to simultaneously monitor thousands of host gene and protein modification levels in response to viral infections, both in vitro and in vivo. This article aims to discuss the most common techniques used for studying virus-induced host changes, as well as useful software tools for subsequent data analysis and the impact these studies have had on the field of virology.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.623
Threshold uncertainty score0.189

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.236
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2012
Admission routes1
Has abstractyes

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