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Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

2008· article· en· 1,403 citations· W2150952126 on OpenAlex· 10.1016/s0140-6736(08)60453-5

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
The Lancet
Topic
Rheumatoid Arthritis Research and Therapies
Field
Medicine
Canadian institutions
Université Laval
Funders
Chugai Pharmaceutical
Keywords
TocilizumabMedicineRheumatoid arthritisPlaceboInternal medicineClinical endpointRheumatologyMethotrexatePopulationRandomized controlled trialArthritisGastroenterologyPathology
Has abstract in OpenAlex
no