Synthesis of curdlan- <i>graft</i> -poly(ethylene glycol) and formulation of doxorubicin-loaded core–shell nanoparticles
Bibliographic record
Abstract
A new core–shell nanoparticle containing the chemotherapeutic drug doxorubicin was formulated via amphiphilic graft copolymer self-assembly using curdlan- graft-poly(ethylene glycol) (curdlan -g-PEG). The graft copolymer was synthesized through the dicyclohexylcarbodiimide ester linkage of carboxylated PEG to the hydroxyl groups of the curdlan backbone. The nanoparticles were 109.9 nm in size and encapsulated doxorubicin in high yield (4%–5% wt/wt). The nanoparticles also controlled the release of doxorubicin over 24 h with a release profile that followed a Fickian diffusion model. The biocompatibility of curdlan- g-PEG was confirmed by hemolysis assay. This is the first nanoparticle formulated using the hydrophobicity of curdlan for concealing the immunomodulatory potential of curdlan within the core.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".