Pd‐PEPPSI‐IPent: An Active, Sterically Demanding Cross‐Coupling Catalyst and Its Application in the Synthesis of Tetra‐<i>Ortho</i>‐Substituted Biaryls
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Development of a cross-coupling catalyst; synthetic chemistry.
This evaluates chemical catalysts for a cross-coupling reaction, not research itself.
Synthetic organometallic catalysis for biaryl cross-coupling; domain chemistry.
Abstract
Incredible Bulk: A series of N-heterocyclic carbene catalysts (see picture) were prepared and evaluated in the Suzuki-Miyaura reaction. A variety of sterically encumbered tetra-ortho-substituted biaryl products were formed from unreactive aryl chlorides using the isopentyl-substituted catalyst at temperatures ranging from 65 degrees C to room temperature. The cyclopentyl-substituted catalyst was virtually inactive, demonstrating that "flexible bulk" is essential to promote these transformations.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Angewandte Chemie International Edition
- Topic
- Catalytic Cross-Coupling Reactions
- Field
- Chemistry
- Canadian institutions
- University of TorontoYork University
- Funders
- —
- Keywords
- Steric effectsCarbeneCatalysisTetraArylChemistryCoupling reactionPolymer chemistryOrganic chemistryCombinatorial chemistryMedicinal chemistry
- Has abstract in OpenAlex
- yes