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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial

2012· article· en· 953 citations· W2152905269 on OpenAlex· 10.1016/s1470-2045(12)70087-6

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.038
GPT teacher head0.404
Teacher spread
0.366 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
The Lancet Oncology
Topic
Lung Cancer Treatments and Mutations
Field
Medicine
Canadian institutions
McGill University Health Centre
Funders
Keywords
AfatinibMedicineErlotinibGefitinibInternal medicineClinical endpointHazard ratioPlaceboLung cancerOncologyPerformance statusChemotherapyAdenocarcinomaRandomized controlled trialSurgeryCancerEpidermal growth factor receptorConfidence intervalPathology
Has abstract in OpenAlex
no