Évaluation de la prévalence d’une carence en thiamine chez des patients insuffisants cardiaques traités à long terme au furosémide
Bibliographic record
Abstract
Resume Objectif : Evaluer la prevalence et les consequences d’une carence en thiamine chez des patients insuffisants cardiaques prenant quotidiennement du furosemide. Mise en contexte : Une grave carence en thiamine peut provoquer une symptomatologie similaire a celle de l’insuffisance cardiaque et etre ainsi un facteur potentiellement aggravant de cette maladie. Resultats : Les 26 patients inclus dans l’etude prenaient une dose moyenne quotidienne de furosemide de 144 ± 69,6 mg. Aucun patient ne presentait de carence plasmatique en thiamine (concentration plasmatique moyenne de 40,8 ± 21,7 nmol/l). La fraction d’ejection ventriculaire gauche des patients ayant un taux de thiamine plasmatique inferieur a la mediane de l’echantillon (35 nmol/l; p = 0,13) n’etait pas significativement inferieure. L’alimentation de trois patients etait carencee en thiamine. Les patients ayant un taux de thiamine plasmatique superieur ou egal a 35 nmol/l tendaient a avoir une meilleure qualite de vie (p = 0,06). Discussion : La prise quotidienne d’un diuretique de l’anse de Henle devrait etre consideree comme un facteur de risque de carence en thiamine, et ce, independamment de la dose recue. Les resultats obtenus semblent indiquer que la diminution du taux de thiamine plasmatique entraine une degradation cliniquement significative de la qualite de vie. Conclusion : Les donnees sont insuffisantes pour conclure a un lien entre la prise d’une forte dose de furosemide et une predisposition a une carence en thiamine plasmatique. Abstract Objective: To evaluate the prevalence and impact of thiamine deficiency in hospitalized heart failure patients taking daily furosemide. Background: Severe thiamine deficiency can cause a symptomatology similar to that of heart failure and can therefore be an exacerbating factor of this disease. Results: The mean daily dose of furosemide in the 26 patients was 144 ± 69.6 mg. None of the patients had thiamine deficiency (mean: 40.8 ± 21.7 nmol/L). Left ventricular ejection fraction was not significantly lower in the patients with a thiamine level < 35 nmol/L, the sample median (p = 0.13). Three patients had a diet deficient in thiamine. The quality of life of the patients with a thiamine level ≥ 35 nmol/L tended to be better (p = 0.06). Discussion: Daily dosing with a loop diuretic should be considered a risk factor for thiamine deficiency, regardless of the dose. The results of the evaluation of quality of life in relation to the thiamine level seem to indicate a clinically significant impact. Conclusion: The data are insufficient to conclude that there is a link between high-dose furosemide and a predisposition to thiamine deficiency.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".