The Role of Pertussis Booster Vaccinations in Adolescents and Adults
Bibliographic record
Abstract
In most developed countries, long-standing vaccination programs for infants and young children have led to substantial decreases in pertussis disease since their introduction in the 1940s. More recently, however, there has been a resurgence of pertussis case reports, most notably among adolescents and adults. Immunity from childhood pertussis vaccinations wanes after several years, but natural boosting through repeated subclinical infection is now uncommon; most adolescents and adults are again susceptible to pertussis. Manifestations of pertussis in these age groups are highly variable, ranging from mild symptoms unlikely to prompt medical care through typical whooping cough. Complications are common and include sleep deprivation, school and work disruptions, rib fractures, and pneumonia. Adolescents and adults not only experience substantial morbidity and complications from pertussis, they play an important role in transmission of Bordetella pertussis to children. Multiple studies have documented that parents and other family members are the main source of pertussis infection in infants. Of particular concern are very young infants, who are at greatest risk for hospitalization and mortality from pertussis, and who are either incompletely vaccinated or unvaccinated. To address these concerns, adolescent/adult-formulation tetanus-diphtheria-acellular pertussis (Tdap) vaccines, sometimes combined with injectable polio vaccine, have been developed. These Tdap vaccines have been shown in clinical trials to be safe and at least as immunogenic against pertussis as their analogous pediatric vaccines. In Canada and the US, Tdap vaccination is recommended for all adolescents and adults < 64 years of age. Emphasis is placed on vaccinating young adolescents and on vaccinating adults (eg, new parents, child-care workers, and certain healthcare-personnel) who have close contact with infants. Canadian experience suggests that Tdap vaccine usage has contributed to further decreases in pertussis. Full control of this disease, however, may require decennial boosting with Tdap vaccine, which is currently under study.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".