Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications
Bibliographic record
Abstract
PURPOSE OF REVIEW: In addition to the crucial role of vascular endothelial growth factor (VEGF)A in vessel development, it has become apparent that the VEGF signaling pathway (VSP) plays an important role during adulthood in the maintenance of tissue homeostasis in normal physiological processes, as well as in pathological conditions. This review will focus on the role of the VSP for proper function of many organs in adult life. RECENT FINDINGS: Although adult angiogenesis is essentially quiescent--with the exception for wound healing and the menstrual cycle--manipulations of the VSP in mice have revealed its much broader and essential role in adult physiology and pathological conditions. Although suppression of the VSP is a promising clinical approach to treat cancer and age-related macular degeneration, it is associated with severe side effects. These adverse reactions caused by systemic VSP suppression in patients and the knowledge that has been gained from mouse models have contributed to our increasing understanding of the vast spectrum of functions that can be attributed to VEGF. SUMMARY: We will review the multifaceted role of VEGF signaling in adult life and highlight how genetic approaches have verified and explained the spectrum of side effects of antiangiogenic therapies using systemic modulation of the VSP. The fascinating parallels that become evident calls for the development of further animal models to address specific questions that could have implications in disease treatments targeting the VSP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".