Methylmalonic Acid in Dialysis Patients
Bibliographic record
Abstract
Propionyl-CoA is a common product of metabolism of essential AA (Val, Thr, Leu, Ile), fatty acids and cholesterol and is further metabolised enzymatically to methyl-malonyl CoA, which is further isomerised to succinyl CoA. Because of the common cofactor (cobalamin) methylmalonic acid (Mma) can serve as an early marker of functional cobalamin deficiency. Purpose of the study: To evaluate possible hidden cobalamin deficiency and the effect of treatment with iv. vit B12 on Mma and tot. homocystein (tHcy) levels in dialysis patients (pts). Methods: 48 HD treated pts, in routine medication folic acid 5 mg/d, pyridoxin 20 mg/d. Measurement of serum levels of Mmk, folic acid, tHcy, cobalamin, blood counts. Healthy patients served as controls for Mma. Vit B12 therapy – cyanocobalamin 1 mg iv. after HD every week for 6 weeks, after 6 weeks 1mg monthly. Results: HD patients: before B12 treatment after B12 Methylmalonic acid 0,904 +/− 0,389 0,554 +/− 0,222 Total homocystein 21,653 +/− 6,851 16,055 +/− 4,896 Mma in EPO treated pts: 0,842 +/− 0,325 0,536 +/− 0,234 Mma in EPO non-treated: 1,028 +/− 0,482 0,590 +/− 0,199 Healthy controls: Mma = 0,305 +/− 0,158 umol/l (max. norm. 0,22) Conclusions: We did not find overt vitamin B12 deficiency in HD pts, however elevated levels of Mma and tHcy raise a question about functional B12 deficiency. Vitamin B12 supplementation improved (decreased) the levels of both methylmalonic acid and homocystein in this subset of patients. Influence of EPO treatment merits further study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".