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Record W2156036056 · doi:10.5779/hypothesis.v1i1.11

Stem Cells - Hope or Hype for Reproductive and Regenerative Medicine?

2008· article· en· W2156036056 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueHypothesis · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAnimal Genetics and Reproduction
Canadian institutionsnot available
Fundersnot available
KeywordsRegenerative medicineStem cellReproductive medicineEngineering ethicsEnvironmental ethicsMedicineBiologyEngineeringCell biologyPhilosophyPregnancyGenetics

Abstract

fetched live from OpenAlex

1. Generally, conditioned media from cells generated to overexpress an antibody are run through a bead column – similar to an immunoprecipitation – and then the bound antibody is eluted off the column. However, how a company generates this antibody can vary (ie, using insect or mammalian cells) as well as the methods used to purify the antibody. This can make a big difference in what additional proteins may be present in the antibody as it is shipped. 2. These experiments in Figure 1 were performed with antibodies, not commercially available, that were generated by 4 different companies. All were raised to detect Receptor X and selected for in vivo use because they inhibit the binding of Receptor X’s ligand. Their use in vivo has been to test whether inhibiting Receptor X can inhibit tumor growth. In general, these antibodies are not different from those commercially available and used in Westerns – yet it is possible that that these antibodies may not be as pure as those you buy commercially.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.083
Threshold uncertainty score0.375

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.059
GPT teacher head0.250
Teacher spread0.191 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it