Early changes in right ventricular function and their clinical consequences in childhood and adolescent dilated cardiomyopathy
Bibliographic record
Abstract
The aim of the paper was to investigate the right ventricle in paediatric dilated cardiomyopathy. We examined 11 patients with dilated cardiomyopathy as well as 12 normal paediatric controls. Cardiac magnetic resonance imaging was performed for ventricular size and function. N-terminal pro-brain natriuretic peptide was collected at this time and the results from the most recent echocardiogram and exercise test were reviewed.We found that patients with dilated cardiomyopathy had significantly faster heart rates, that is, 85 versus 65 beats per minute, lower left ventricular ejection fraction, that is, 42 versus 61%, and right ventricular ejection fraction of 44 versus 54%, lower left and right ventricular stroke volumes, that is, 35.5 versus 49.5 millilitres per square metre and 40.9 versus 56.4 millilitres per square metre, respectively, and lower mitral and tricuspid valve inflow e/a wave velocity ratios of 2.02 versus 2.80 and 1.25 versus 2.58, respectively, than the controls. Tricuspid valve annulus velocity, measured by tissue Doppler echocardiography, correlated with right ventricular ejection fraction (r = 0.60, p = 0.05). Right ventricular ejection fraction and indexed right ventricular end-diastolic volume correlated with N-terminal pro-brain natriuretic peptide (r = -0.67, p = 0.03, r = 0.65, p = 0.04, respectively), and right ventricular ejection fraction correlated with the oxygen uptake at the anaerobic threshold (r = 0.67, p = 0.049). Neither left ventricular ejection fraction nor left ventricular volume correlated with N-terminal pro-brain natriuretic peptide or exercise tolerance. The right ventricular function is decreased in the early stages of dilated cardiomyopathy. Right ventricular size and ejection fraction may be important indicators of sub-clinical cardiac failure and we suggest monitoring them routinely in dilated cardiomyopathy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".