Energy deficiency alters behaviours involved in transmission of<i>Heligmosomoides polygyrus</i>(Nematoda) in mice
Bibliographic record
Abstract
Independent studies have shown that animal behaviour is affected by nutritional deficiency and that host behaviour influences parasite transmission. The objectives of this study were to determine whether energy deficiency alters the behaviour profile of mice and the rate of exposure of mice to naturally acquired Heligmosomoides polygyrus (Nematoda) larvae. Outbred CF-1 and CD-1 female mice were fed either a control or an energy-deficient (65% of control) diet for 7 days, after which time, the mice fed the deficient diet had consumed signficantly less energy, had lower rectal temperatures, and lower masses (CD-1 mice only) compared with control mice. On day 7, mice were placed individually in natural transmission arenas containing damp peat moss and parasite larvae for 6 h, during which time, each mouse was observed 60 times and her behaviour recorded. All mice were then returned to standard caging and fed the energy-sufficient diets to eliminate confounding effects of energy deficiency on the host immune response over the following 8 days. At necropsy, parasite numbers were significantly lower in the energy-deficient mice of both strains. The behaviour profile differed significantly between diet groups and between strains; deficient mice of both strains groomed less and dug in the peat substrate less than control mice. The frequency of grooming was positively correlated with worm burden in both strains, the frequency of mouthing the peat moss and of sleeping were positively associated with worm burden in CD-1 mice, and the frequency of standing and walking low was positively associated with worm burden in CF-1 mice. These results indicate that grooming and contact with the peat moss are important behaviours in transmission of H. polygyrus, that energy deficiency causes a decrease in the frequency of these behaviours, and that these behavioural changes may contribute to reduced parasite transmission in mice fed the energy-restricted diet.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".