Bibliographic record
Abstract
Cerebral amyloid angiopathy (CAA) can occasionally present with encephalopathy, unsteadiness and seizures, as a result of an inflammatory response to the deposition of beta–amyloid within the cerebral blood vessels and leptomeninges. In this case report, we describe a patient who has responded very favourably to immunosuppression. A previously fully independent 67 year old lady presented with a short history of confusion, worsening unsteadiness and self neglect. Neurologically, she was disorientated, dyspraxic with limb weakness and ataxia. MRI showed extensive bilateral white matter change and oedema throughout both hemispheres with numerous grey–white interface microhaemorrhages. These radiological findings were suggestive of an unusual form of cerebral amyloid angiopathy and related leukoencephalopathy. The patient received pulsed intravenous methylprednisolone, followed by regular oral prednisolone. Three weeks later, she began a slow but steady clinical improvement. She relapsed when the prednisolone was tapered off, but currently, she is well maintained on prednisolone and azathioprine, and regained her independence. Although CAA related inflammation is rare, it should be thought of in the differential for extensive leukoencephalopathy and a trial of steroids should be considered early to promote recovery.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".