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Record W2158243172 · doi:10.1002/wdev.26

Internalizing the vegetal cell mass before and during amphibian gastrulation: vegetal rotation and related movements

2011· review· en· W2158243172 on OpenAlexafffund
Rudolf Winklbauer, Erich W. Damm

Bibliographic record

VenueWiley Interdisciplinary Reviews Developmental Biology · 2011
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPluripotent Stem Cells Research
Canadian institutionsUniversity of Toronto
FundersCanadian Institutes of Health Research
KeywordsBlastocoelGastrulationPolarity in embryogenesisEndodermBiologyAnatomyMesodermIngressionEctodermCell biologyEmbryoEmbryogenesisEmbryonic stem cell

Abstract

fetched live from OpenAlex

The movement of the prospective mesoderm and endoderm to the interior of the amphibian embryo starts in the vegetal cell mass well before the onset of overt gastrulation. By an animally directed movement of cells, the vegetal mass constricts its outer part and expands its inner region including the blastocoel floor, in a process of pregastrulation emboly. Further internalization of the vegetal region has been studied in the Xenopus embryo. At the onset of gastrulation, vegetal rotation sets in at the periphery of the vegetal cell mass, first dorsally and then spreading laterally and ventrally. It consists of an intense inward surging of cells due to active cell rearrangements that can be observed in explants of the vegetal cell mass. In its course, the blastocoel floor expands further and becomes apposed to the blastocoel roof. The boundary between apposed floor and roof forms Brachet's cleft. Another effect of vegetal rotation is the downward and inward movement of the mesodermal marginal zone, constituting the first phase of involution. Together, the upward and outward movement of the peripheral vegetal mass and the downward and inward translocation of the marginal zone lead to an apparent rotation of the whole peripheral region of the gastrula. Vegetal rotation continues to contribute to endoderm internalization to near the end of gastrulation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.313
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2011
Admission routes2
Has abstractyes

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