Primary CNS Malignant Melanoma Associated With a Contralateral Nevus of Ota in an African-American Female: Unique Case Report
Bibliographic record
Abstract
Background: Primary CNS melanoma is a rare neoplasm of the brain. Nevus of Ota is an area of macular, melanocytic pigmentation of the sclera and skin around the eye. Association between intracranial melanocytic neoplasms and Nevus of Ota has previously been described in case reports. The two lesions tend to occur ipsilaterally and in Caucasian patients. We present the first documented case of a primary malignant CNS melanoma contralateral to a Nevus of Ota in an African-American patient. Case Discussion: A 32-year-old female presented with intermittent numbness involving the left side of her face, arm, and leg. General physical exam revealed a large area of hyperpigmentation involving the left side of her face, especially around the eye and upper cheek, consistent with Nevus of Ota. Neuroimaging revealed a hemorrhagic intraparenchymal mass in the right frontotemporal region. Surgical resection of the lesion was performed, and pathology was consistent with primary CNS malignant melanoma. Conclusion: Primary CNS melanocytic neoplasms and Nevus of Ota share a similar embryological origin. Thus, the associated occurrence of the two is not surprising. We present a unique case of primary CNS malignant melanoma associated with a contralateral Nevus of Ota in an African-American patient. Primary CNS melanoma should be considered in the differential diagnosis of any patient with a Nevus of Ota who is found to have an intracranial mass.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".