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Record W2159723237 · doi:10.1017/cbo9780511471001.005

Anatomy and physiology of hematopoiesis

2006· book-chapter· en· W2159723237 on OpenAlexaff
Connie J. Eaves, Allen Eaves

Bibliographic record

VenueCambridge University Press eBooks · 2006
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicZebrafish Biomedical Research Applications
Canadian institutionsTerry Fox Research Institute
Fundersnot available
KeywordsHaematopoiesisBiologyLineage (genetic)Hematologic diseaseNeuroscienceProcess (computing)PhysiologyAnatomyCell biologyStem cellPathologyDiseaseMedicineGeneticsComputer scienceGene

Abstract

fetched live from OpenAlex

Hematopoiesis refers to all aspects of the process of blood cell production. Understanding this process requires a comprehensive knowledge of both the anatomy and the physiology of the blood-forming system. Here, the anatomy of the hematopoietic system is viewed as the distinguishable stages of differentiation that together make up the complete hierarchy of hematopoietic cells. These stages reflect the changes that initially endow cells in the embryo with hematopoietic differentiation potential (a step referred to as specification), in addition to those that subsequently constitute the processes of lineage restriction and terminal differentiation. The physiology of hematopoiesis refers to the dynamic aspects of these events and covers issues such as the determination of alternate outcomes, at both the cellular and molecular level, as well as their modulation during development and in response to injury or disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.008
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.002
Scholarly communication0.0020.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0080.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.225
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2006
Admission routes1
Has abstractyes

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