MétaCan
Menu
Back to cohort
Record W2159746250 · doi:10.1016/j.jcf.2008.03.009

Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice

2008· review· en· W2159746250 on OpenAlexafffund
Carlo Castellani, Harry Cuppens, Milan Maçek, J.J. Cassiman, Eitan Kerem, Peter R. Durie, Elizabeth Tullis, B.M. Assael, C. Bombieri, Anthony Brown, Teresa Casals, Mireille Claustres, Garry R. Cutting, Elisabeth Dequeker, J.A. Dodge, Iolo Doull, Philip M. Farrell, Claude Férec, Emmanuelle Girodon, Magnus Johannesson, Batsheva Kerem, Michael R. Knowles, À. Munck, Pier Franco Pignatti, Dragica Radojković, Paolo Rizzotti, Martin Schwarz, Manfred Stuhrmann, Maria Tzetis, Julian Zielenski, J.S. Elborn

Bibliographic record

VenueJournal of Cystic Fibrosis · 2008
Typereview
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsSt. Michael's HospitalSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesAbbott DiagnosticsHospital for Sick ChildrenCystic Fibrosis FoundationAOP OrphanGenome CanadaChiesi Farmaceutici
KeywordsCystic fibrosisMedicineInterpretation (philosophy)Clinical PracticeIntensive care medicineMutationInternal medicineFamily medicineGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.035
metaresearch head score (Gemma)0.064
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.035
Threshold uncertainty score0.184

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0350.064
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0060.002
Bibliometrics0.0070.005
Science and technology studies0.0010.003
Scholarly communication0.0040.005
Open science0.0060.003
Research integrity0.0080.008
Insufficient payload (model declined to judge)0.0030.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.080
GPT teacher head0.426
Teacher spread0.346 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations591
Published2008
Admission routes2
Has abstractno

Explore more

Same venueJournal of Cystic FibrosisSame topicCystic Fibrosis Research AdvancesFrench-language works237,207