Dynamic Bayesian Networks (DBNs) Demonstrate Impaired Brain Connectivity During Performance of Simultaneous Movements in Parkinson's Disease','','','','','','','','964','967',
Bibliographic record
Abstract
Many symptoms of brain diseases may be caused by altered connectivity between brain regions, necessitating the development of suitable models for inferring effective connectivity in fMRI. Inspired by recent graphical approaches for inferring connectivity, here we propose dynamic Bayesian networks (DBNs) for learning the effective connectivity between a priori specified brain regions of interest (ROIs). We applied this method to fMRI data from Parkinson's disease (PD) and normal subjects performing a simultaneous movement task. Compared to the normal subject, the effective connectivity between motor regions was severely impaired in the PD subject, which was minimally ameliorated with L-dopa medication. These results imply a functional disconnection between brain regions far downstream from the basal ganglia, the initial site of pathology in PD. We suggest that DBNs provide a powerful framework to assess functional connectivity in fMRI studies of brain pathologies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".