Angiotensin-converting enzyme inhibitors and atherosclerotic plaque: a key role in the cardiovascular protection of patients with coronary artery disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In EUROPA, the angiotensin-converting enzyme inhibitor (ACEI) perindopril on top of other preventative therapies reduced the risk of major coronary events (cardiovascular death, myocardial infarction, resuscitated cardiac arrest) by 20% when compared with placebo (P = 0.0003) in patients with stable coronary artery disease (CAD). These cardiovascular benefits may be attributable not only to the blood pressure-lowering effect of the drug, but also potentially to a direct cardioprotective vascular effect as determined in two substudies of EUROPA. Analysis of intravascular ultrasound data from the PERSPECTIVE substudy indicated that perindopril treatment may be associated with favourable patterns of coronary remodelling that are associated with plaque stabilization and may induce regression of non-calcified lesions. In the PERTINENT substudy, there were reductions in markers of coronary vascular endothelial cell dysfunction and the rate of endothelial cell apoptosis in perindopril recipients. Experimental data suggest an advantage of perindopril over other ACEIs at the level of tissue ACE inhibition and relative selectivity for bradykinin, which may explain the mechanism of the beneficial effect of perindopril on the endothelium. These differences may underpin the differential results in large clinical trials of ACEIs in patients with stable CAD.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it