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Common variant at 16p11.2 conferring risk of psychosis
Stacy Steinberg, Simone de Jong, Manuel Mattheisen, Javier Costas, Ditte Demontis, Stéphane Jamain, Olli Pietiläinen, Kuang Lin, Sergi Papiol, Johanna Huttenlocher, Engilbert Sigurðsson, Evangelos Vassos, Ina Giegling, René Breuer, G. T. Fraser, Nicholas Walker, Ingrid Melle, Srdjan Djurovic, Ingrid Agartz, Annamari Tuulio‐Henriksson, Jaana Suvisaari, Jouko Lönnqvist, Tiina Paunio, Line Olsen, Thomas Folkmann Hansen, Andrés Ingason, Matti Pirinen, E Strengman, David M. Hougaard, Torben Ørntoft, Michael Didriksen, Mads V. Hollegaard, Merete Nordentoft, Л. И. Абрамова, В. Г. Каледа, Manuel Arrojo, Julio Sanjuán, Celso Arango, Bruno Étain, Frank Bellivier, A. Méary, Franck Schürhoff, Andreı̈ Szöke, Michele Ribolsi, Valentina Magni, Alberto Siracusano, Swetlana Sperling, Moritz J. Rossner, Claus Christiansen, Lambertus A. Kiemeney, Barbara Franke, Leonard H. van den Berg, Jan H. Veldink, Sarah Curran, Patrick Bolton, Martin Poot, Wouter Staal, Karola Rehnström, Helena Kilpinen, Christine M. Freitag, Jobst Meyer, Patrik K. E. Magnusson, Evald Sæmundsen, Igor Martsenkovsky, I Bikshaieva, I.I. Martsenkovska, O.S. Vashchenko, Marija Raleva, K Paketchieva, Branislav Stefanovski, Naser Durmishi, Milica Pejović-Milovančević, Dušica Lečić Toševski, Teimuraz Silagadze, N Naneishvili, Nina Mikeladze, Simon Surguladze, John B. Vincent, Anne Farmer, Philip B. Mitchell, A. Jordan Wright, Peter R. Schofield, Janice M. Fullerton, Grant W. Montgomery, Nicholas G. Martin, I. Alex Rubino, Ruud van Winkel, Günter Kenis, János Réthelyi, István Bitter, Lars Terenius, Erik G. Jönsson, S C Bakker, Jim van Os, Assen Jablensky, Marion Leboyer, Elvira Bramon, John Powell, Robin Murray, Aiden Corvin, Michael Gill, Derek W. Morris, F. Anthony O’Neill, Kenneth S. Kendler, Brien P. Riley, Nick Craddock, Michael J. Owen, Michael O‘Donovan, U. Thorsteinsdottir, Augustine Kong, Hannelore Ehrenreich, Ãngel Carracedo, В. Е. Голимбет, Ole A. Andreassen, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Thomas Werge, Roel A. Ophoff, Markus M. Nöthen, Marcella Rietschel, Sven Cichon, Mirella Ruggeri, Sarah Tosato, Aarno Palotie, David St Clair, Dan Rujescu, David Collier, Hreinn Stefánsson, Kāri Stefánsson
Bibliographic record
VenueMolecular Psychiatry · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomic variations and chromosomal abnormalities
Canadian institutionsCentre for Addiction and Mental Health
FundersH. Lundbeck A/SHersenstichtingXunta de GaliciaCentro de Investigación Biomédica en Red de Salud MentalMedical Research CouncilUniversität des SaarlandesNational Institute of Mental HealthVetenskapsrådetMax-Planck-GesellschaftNorges ForskningsrådAcademy of FinlandStrategiske ForskningsrådEuropean CommissionUniversity of OxfordBundesministerium für Bildung und ForschungMassachusetts General HospitalNational Institute for Health and Care ResearchAutism SpeaksSundhed og Sygdom, Det Frie ForskningsrådBritish Heart FoundationWellcome TrustHelsingin YliopistoEli Lilly and Company
KeywordsPsychosisPsychologyPsychiatrySchizophrenia (object-oriented programming)MedicineGeneticsBiology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.437
Threshold uncertainty score0.697
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.005
GPT teacher head0.222
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations106
Published2012
Admission routes1
Has abstractno