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Record W2162258804 · doi:10.1016/s0140-6736(10)60588-0

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

2010· review· en· W2162258804 on OpenAlexafffund
Thomas J. Wang, J. Brent Richards, Bryan Kestenbaum, Joyce B. J. van Meurs, Diane J. Berry, Douglas P. Kiel, Elizabeth A. Streeten, Claes Ohlsson, Daniel L. Koller, Leena Peltonen, Jason D. Cooper, Paul F. O’Reilly, Denise K. Houston, Nicole L. Glazer, Liesbeth Vandenput, Munro Peacock, Julia Shi, Fernando Rivadeneira, Mark I. McCarthy, Anneli Pouta, Ian H. de Boer, Massimo Mangino, Bernet Kato, Deborah J. Smyth, Sarah L. Booth, Paul F. Jacques, Greg Burke, Mark O. Goodarzi, Ching‐Lung Cheung, Myles Wolf, Kenneth Rice, David Goltzman, Nick Hidiroglou, Nicholas J. Wareham, Lynne J. Hocking, Deborah Hart, Nigel Arden, Cyrus Cooper, Suneil Malik, William D. Fraser, Anna-Liisa Hartikainen, Guangju Zhai, Helen M. Macdonald, Nita G. Forouhi, Ruth J. F. Loos, David M. Reid, Alan J. Hakim, Elaine Dennison, Ching‐Ti Liu, Chris Power, Helen E. Stevens, Laitinen Jaana, Ramachandran S. Vasan, Nicole Soranzo, Jörg Bojunga, Bruce M. Psaty, Mattias Lorentzon, Tatiana Foroud, Tamara B. Harris, Albert Hofman, John-Olov Jansson, Jane A. Cauley, André G. Uitterlinden, Quince Gibson, Marjo‐Riitta Järvelin, David Karasik, David S. Siscovick, Michael J. Econs, Stephen B. Kritchevsky, José C. Florez, John A. Todd, Josée Dupuis, Elina Hyppönen, Timothy D. Spector

Bibliographic record

VenueThe Lancet · 2010
Typereview
Languageen
FieldMedicine
TopicVitamin D Research Studies
Canadian institutionsPublic Health Agency of CanadaHealth CanadaMcGill University Health CentreMcGill UniversityJewish General Hospital
FundersNational Human Genome Research InstituteNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute of Child Health and Human DevelopmentNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesBiocenter, University of OuluDirectorate for Biological SciencesNational Institutes of HealthMedical Research CouncilNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesVersus ArthritisErasmus Medisch CentrumNational Eye InstituteAgricultural Research ServiceAcademy of FinlandNational Institute on AgingNational Institute for Health and Care ResearchNederlandse Organisatie voor Wetenschappelijk OnderzoekUniversity College LondonBiotechnology and Biological Sciences Research CouncilWellcome TrustOulun YliopistoHelsingin YliopistoSchool of Medicine, Boston UniversityEuropean CommissionZonMwJohns Hopkins UniversityU.S. Department of AgricultureKing's College LondonJuvenile Diabetes Research Foundation InternationalCanadian Institutes of Health ResearchAmerican Heart Association
KeywordsVitamin D and neurologyGenome-wide association studyGenotypeBiologyGeneticsLocus (genetics)vitamin D deficiencyHeritabilityGenetic associationCYP24A1Calcitriol receptorInternal medicineMedicineSingle-nucleotide polymorphismEndocrinologyGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0020.004
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.069
GPT teacher head0.387
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,542
Published2010
Admission routes2
Has abstractno

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