Novel memory mutants in Drosophila: Behavioral characteristics of the P-Insertional mutant Ent2 P124
Bibliographic record
Abstract
The Drosophila mutant P124, carrying insertion of P (lacW) vector in the second chromosome on the background of the w mutation in the X chromosome, was previously isolated as showing memory deficiency after courtship conditioning. Here we report additional features of the mutant phenotype: (1) abnormal adaptation to darklight transition; (2) impaired perception by males of nuances of visual image of a female, specifically, of her fine movements such as preening and ovipositor extrusion; (3) subnormal performance index after odor-shock conditioning. These abnormalities are not related to a deficit of the eye screening pigments because they are also revealed on the background of the normal w + allele in the X chromosome. The visual and cognitive impairments are independent pleiotropic effects of the mutation. The mutation is caused by insertion of the P vector 12 nucleotides upstream of the transcription start of the gene Ent2 (equilibrative nucleoside transporter 2). Ent2 P124 is the second mutant allele of this gene found in Drosophila. The genetic variability in Ent2 locus should be considered as a factor of risk for development of mental retardation and disorders of visual perception.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".