Metallo‐Controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self‐Assembly by Metal‐Ion Coordination
Why this work is in the frame
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Bibliographic record
Abstract
Abstract The introduction of controllable dynamic features into synthetic receptors represents a step towards “smart” adaptive nanodevices. We report herein our studies on the construction of dynamic molecular tweezers in which the binding of a substrate is allosterically controlled through shape switching of the receptor induced by metal‐ion coordination. 1D, 2D NMR spectroscopy and X‐ray crystallography were used to identify the nature of the metallosupramolecular entity generated. The presence of large aromatic naphthalene diimide moieties on the scaffold of the molecular tweezers strongly influences their coordination‐driven self‐assembly. It was found that these additional stacking interactions lead to the cooperative formation of a homocomplex, to the self‐sorted assembly of a hetero complex, and to the binding of non‐coordinating aromatic guests.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it