Pterocarpadiols A–D, Rare 6a,11b-Dihydroxypterocarpans from Derris robusta
Bibliographic record
Abstract
The genus Derris (Leguminosae) contains about 800 species, widely distributed in tropical and subtropical parts of the world [ 1 ]. The bark and leaves of Derris species are commonly utilized as folk medicine to treat human diseases such as arthritis and eczema [ 2 ]. The extracts and reported chemical constituents exhibit antioxidant, antibacterial and pesticidal activities [ 2 ]. Previous studies show the genus is a rich source of flavonoids, isoflavonoids, pterocarpans and rotenoids [ 2 ]. As part of a BioBioPha [ http://www.chemlib.cn ] objective to assemble a large-scale natural product library very valuable in the discovery of new drug leads from nature [ 3 – 7 ], the phytochemical investigation on the twigs and leaves of Derris robusta led to the isolation of four new 6a,11b-dihydroxypterocarpans, namely pterocarpadiols A–D ( 1 – 4 ), together with 10 known pterocarpans: 1,11b-dihydro-11b-hydroxymaackiain ( 5 ) [ 8 ], 1,11b-dihydro-11b-hydroxymedicarpin ( 6 ) [ 8 ], pisatin ( 7 ) [ 9 ], variabilin ( 8 ) [ 10 ], 6a-hydroxymaackiain ( 9 ) [ 11 ], 6a-hydroxymedicarpin ( 10 ) [ 12 ], maackiain ( 11 ) [ 13 ], medicarpin ( 12 ) [ 14 ], 3-hydroxy-8,9-methylenedioxypterocarpene ( 13 ) [ 15 ], and anhydroglycinol ( 14 ) [ 16 ]. Among the known pterocarpans, compounds 5 – 10 and 14 were isolated from the genus for the first time. This paper reports the isolation and structure elucidation of pterocarpadiols A–D.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".