P1‐263: ABERRANT FUNCTIONAL CONNECTIVITY OF THE THALAMUS IN A ONE‐YEAR FOLLOW‐UP STUDY OF MILD COGNITIVE IMPAIRMENT
Bibliographic record
Abstract
Most mild cognitive impairment (MCI) patients shared the same pathophysiology and similar symptoms with Alzheimer's disease (AD). Hence, it is great important to fully understand the clinical and pathophysiological changes in the MCI stage for the earlier diagnosis of AD. However, there were only few studies aiming at the longitudinal alteration of functional connectivity in MCI till now. The thalamus occupies the central position of human brain and was also considered to be central to the cortical functions. Moreover, the thalamus has been repeatedly found to be involved in some important resting-state networks, such as the default mode network, which is closely related to episodic memory. Increasing evidences have confirmed the significant volume loss and disrupted connectivity pattern of the thalamus in AD/MCI subjects. The present study is to investigate alteration of thalamic functional connectivity in patients with MCI during a one year follow-up. Neuropsychological tests and thalamic functional connectivity based on resting state functional magnetic resonance imaging (fMRI) were evaluated in 13 MCI subjects (age 74.5±8.7years, gender 8M/5F) both at the baseline and one year later. After mean 13 ± 2.2 months, one MCI subject converted to mild AD. The Montreal cognitive assessment (MoCA) score decreased significantly over the period (23.7±2.5 versus 21.7±4.7, p = 0.04), while the mini-mental state examination (MMSE) score decreased numerically in the follow-up (27.3±1.8 versus 25.8±3.4, p =0.10). Compared to the baseline, the MCI patients demonstrated decreased functional connectivity between the left thalamus and left inferior parietal cortex (IPC), left putamen and right cerebellar posterior lobe one year later. Decreased functional connectivity was also detected between the right thalamus and left putamen in the follow-up MCI. We suggest that the MoCA can be used as an effective tool in longitudinal studies of MCI. The impaired functional connection between the thalamus and various brain regions which are involved with higher cognition functions may be associated with the progression of illness in the MCI subjects. These results provided new evidence for the longitudinal alteration of the functional abnormality in the MCI. The brain regions exhibiting significant differences in functional connectivity of the bilateral thalamus in MCI patients. The color bar represents the strength of functional connectivity (p<0.01, cluster size >30 voxels). The individually longitudinal comparisons in the identified brain regions which showed altered functional connectivity in follow-up in the MCI patients. A represents the regions showed altered functional connectivity with the left thalamus. B represents the regions showed altered functional connectivity with the right thalamus. P value represents the significant between the baseline and the follow-up by using pair two-sample t-test.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".