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Record W2164577006 · doi:10.1056/nejme038167

Letrozole after Tamoxifen for Breast Cancer — What Is the Price of Success?

2003· letter· en· W2164577006 on OpenAlexaboutno aff
John Bryant, Norman Wolmark

Bibliographic record

VenueNew England Journal of Medicine · 2003
Typeletter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEstrogen and related hormone effects
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineTamoxifenClinical trialBreast cancerLetrozoleAlternative medicineOncologyRandomized controlled trialCancerFamily medicineGynecologyInternal medicine

Abstract

fetched live from OpenAlex

In this issue of the Journal, Goss et al.1 report results from a trial that will have a considerable effect on the treatment of early-stage breast cancer. The study was led by the National Cancer Institute of Canada Clinical Trials Group and was a joint effort of the North American Intergroup and the Breast International Group. These organizations are to be commended for a well-conceived and well-conducted clinical trial. Their work is an excellent example of the way in which clinical-trial organizations can work together efficiently and expeditiously to investigate clinical questions of common interest.Previous trials have shown that . . .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.114
Threshold uncertainty score0.508

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.250
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations43
Published2003
Admission routes1
Has abstractyes

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