Connexin 43 Enhances the Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
Bibliographic record
Abstract
The direct cell-to-cell communication is performed by gap junctions (GJ) composed of connexin (Cx), a large protein family with a number of subtypes. GJ channels allow the propagation of electrical impulse and the transfer of small molecules (up to 1,000 to 1,500 Da) between two neighbouring cells (Figure 1). And it has also become clear that different combination of Cxs are expressed in different tissues with temporal specificity during development or tissue differentiation (Paul, 1995). By such a rigid regulation, Cxs contribute to maintain cellular homeostasis in many organs. On the contrary, expression levels of Cx proteins are often decreased in many cancers, and restoring their levels has been shown to have antitumor effects. In this concept, there is a possibility to establish a new cancer therapy based on tumor-suppressive functions of Cxs for refractory cancers, such as mesothelioma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".