Sequence Analysis of a Hoxa4 - Hoxa5 Intergenic Region Including Shared Regulatory Elements
Bibliographic record
Abstract
The dynamic patterns of Hox gene expression are generated by a combination of regulatory elements differentially controlling Hox gene transcription in a spatio-temporal and tissue-specific fashion. Regulatory elements can either be exclusive for a particular gene, shared by neighboring Hox genes, or be competed for by different promoters. Our interest in Hoxa5 gene function and regulation have led us to localize Hoxa5 cis-acting regulatory elements in the intergenic region between the Hoxa4 and Hoxa5 genes and involved in Hoxa5 organ expression. Mapping of the region and sequence analysis revealed some discrepancies with a previously published sequence. Here, we report an additional DNA fragment of 282 base pairs that possesses high homology with the human HOX sequence, and contains potential binding sites for trans-acting factors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".