Bioactivating electrically conducting polypyrrole with fibronectin and bovine serum albumin
Bibliographic record
Abstract
Electrically conducting polypyrrole (PPy) and its composite materials are useful in interfacing electrical components and cells or living tissue. In recent years, significant efforts have been made to bioactivate PPy by incorporating biomolecules. The main objective of this work was to chemically bioactivate PPy particules by incorporating fibronectin (FN) and bovine serum albumin (BSA). Modified PPy particles were synthesized through a water-in-oil emulsion polymerization. XPS and FTIR confirmed the presence of biomolecules on the PPy particles, and the surface morphology was observed by SEM. A four-point probe was used to measure the conductivity of the newly synthesized PPy particles, which was in the range of 10(-1) S cm(-1). Conductive biodegradable membranes were prepared with 5 and 10% (wt/wt) PPy to poly(L,L-lactide) (PPy/PLLA). The contact angles of each synthesized membrane were approximately 75 degrees , supporting their usefulness for cell culture. The cultured human skin fibroblasts demonstrated normal morphology and significantly higher adhesion and spreading on the PPy/PLLA approximately FN membrane than on the unmodified PPy/PLLA membrane. On the other hand, the PPy/PLLA approximately BSA membranes showed decreased cell adhesion. Bioactivated PPy may be useful in tissue engineering to fabricate conducting biodegradable scaffolds with either improved or reduced cell adhesion properties for various cell culture and in vivo applications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".