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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

2012· article· en· 744 citations· W2165575701 on OpenAlex· 10.1016/j.cell.2012.02.053

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Cell
Topic
Melanoma and MAPK Pathways
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
National Institute of General Medical SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Institute of Environmental Health SciencesCanadian Institutes of Health Research
Keywords
KinomeTriple-negative breast cancerMEK inhibitorBiologyCancer researchMAPK/ERK pathwayReprogrammingReceptor tyrosine kinaseKinaseTrametinibGene knockdownCancerCell biologyBreast cancerApoptosisBiochemistryCellGenetics
Has abstract in OpenAlex
no