One-pot syntheses, coordination, and characterization of application-specific biodegradable ligand-polymers
Bibliographic record
Abstract
Syntheses and chelation of tailored biodegradable polymers to rhenium for medicinal applications are described. A group of bifunctional ligand-initiators consisting of a chelating end for metal complexation and a hydroxyl end suitable to initiate polymerization was utilized in the ring-opening polymerization of l-lactide. The resulting biodegradable ligand-polymers were equipped with a tridentate donor set to coordinate specific metal ions. All synthesized compounds were characterized by IR spectroscopy, 1D/2D NMR spectroscopy and MALDI-TOF mass spectrometry, confirming successful polymerization and coordination to the [Re(CO)(3)](+) core. The pliability of designing application-specific polymers with respect to the nature of the metal ion facilitates extending the application of these biodegradable polymers to early detection of diseases (imaging) and radiotherapy of cancers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".