Effects of long-term parenteral administration of vitamin B<sub>6</sub>on B<sub>6</sub>status and some aspects of the glucose and protein metabolism of early-weaned piglets
Bibliographic record
Abstract
The present experiment aimed to determine the effect of feeding level and parenteral supplements of vitamin B6 (pyridoxine) on B6 status as well as on glucose, C-peptide, insulin, alpha-amino-N and urea after a gastric bolus of glucose in weaned piglets; the plasma tryptophan, xanthurenic acid and kynurenine responses to a gastric bolus of tryptophan were also measured. Forty-two piglets weaned at 2 weeks of age were distributed in seven blocks of six animals each. Within each block, the animals were assigned to the following factorial treatments: two levels of feeding (28 (F28) and 56 (F56) g/kg(0.75) per d) administered by gastric-tube feeding and three levels of parenteral (intramuscular injections) vitamin B6 (0 (B60), 15 (B615) and 30 (B630) mg/d). In B60 piglets, a decrease of 30 % and 20 % in erythrocyte and plasma pyridoxal-5-phosphate respectively, were observed during the 2 weeks post-weaning. In supplemented piglets, the erythrocyte pyridoxal-5-phosphate was maximised in B615 piglets at a level 3-4 times higher than in B60 piglets (P < 0.003). However, in plasma the maximal pyridoxal-5-phosphate concentration was reached in F28-B630 piglets (P < 0.058). The glucose and insulin responses to a gastric bolus of glucose were lower, and the post-bolus decrease of glucose was slower, in F28 than in F56 piglets (P < 0.0001). The insulin:C-peptide ratio was 25 % greater in B615 piglets (P < 0.082). After the bolus of glucose, the aminoacidaemia decreased differentially according to treatments (P < 0.047), while the uraemia was at least 2-fold higher (P < 0.001) in F28 piglets than in F56 piglets and tended to be maximised in B630 piglets (P < 0.074). The response of plasma tryptophan to the gastric bolus of tryptophan was 11 % lower in B630 piglets (P < 0.057). The plasma concentration of kynurenine increased continuously during the post-bolus period and this response was more marked in F56 (P < 0.002) and in B630 piglets (P < 0.02). Xanthurenic acid was undetectable in any of the treatments. The measurements on pyridoxine status suggest that the present basal dietary level of B6 (7.7 mg/kg) was not sufficient to cover the metabolic needs. For many criteria, an optimal level was reached at 15 mg/d parenteral B6 but the response of urea to glucose bolus suggests that 30 mg/d was detrimental. Further studies are necessary to determine the dietary level of B6 equivalent to the present optimal parenteral supplements and its eventual effects on B6 status and post-weaning growth performance of piglets.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".