Amphotericin B-Deoxycholate is as Effective and Safe as the Costly Amphotericin B Colloidal Dispersion in the Treatment of Paediatric Invasive Fungal Infections
Bibliographic record
Abstract
Amphotericin B deoxycholate (AmBD) and amphotericin B colloidal dispersion (AmBCD) are the two most commonly used antifungals for invasive fungal infections (IFI) among paediatric patients. The objective of this pilot study was to compare the efficacy, adverse effects and cost-effectiveness between AmBD and AmBCD in the treatment of IFI among paediatric patients admitted at Universiti Kebangsaan Malaysia Medical Centre (UKMMC).Methods: Secondary data analysis of the medical records of all paediatric patients with IFI was obtained and data extraction was performed for patients admitted between July 1, 2006 and June 30, 2011. Efficacy of treatment was determined and reports of adverse effects were noted.Results: Between July 1, 2006 and June 30, 2011, thirty-five patients received AmBD-only treatment and five patients received AmBCD-only treatment. Twenty-four patients were males and the mean age was 7.18 (SD 4.59) years. On average, the AmBCD treatment course was significantly more expensive than AmBD (p
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".