Gonadal development and endocrine responses in Japanese medaka (<i>Oryzias latipes</i>) exposed to<i>o,p</i>′-DDT in water or through maternal transfer
Bibliographic record
Abstract
Abstract Various isomers and metabolites of DDT disrupt endocrine systems and gonadal development in fish and wildlife, and o,p′-DDT has been shown to be an relatively potent estrogen agonist. In this study, we exposed Japanese medaka (Oryzias latipes) to o,p′-DDT using two exposure protocols: direct exposure of early life stages to aqueous solutions from 1 to 100 d posthatch and exposure of female medaka to aqueous solutions, followed by mating with unexposed males to produce offspring that were exposed through mechanisms of maternal transfer. In treatments with direct aqueous exposures, an intersex condition of the gonad (testis-ova) was observed in male medaka exposed at early life stages to nominal o,p′-DDT concentrations of 50, 10, and 5 μg/L, indicating that this estrogen agonist can alter gonadal development when exposure occurs continuously over the period of gonadal differentiation. Comparisons with previously published data on the induction of testis–ova by exposure to nonylphenol (NP) and octylphenol (OP) indicated that the relative potencies for induction of intersex in medaka are o,p′-DDT &gt; NP ≈︁ OP, which is not consistent with the relative estrogenic potencies of OP &gt; NP &gt; o,p′-DDT observed in the yeast estrogen screening (YES) assay. In the maternal transfer protocol, no testis-ova were observed in the offspring, although there was some delay in time to hatch of the offspring. Medaka exposed by maternal transfer showed no other toxicological responses during early life stages, but when treated fish reached sexual maturity, the females showed more advanced development of oocytes. In addition, when medaka exposed by maternal transfer were subsequently exposed at 10 months of age to 17β-estradiol (12 mg/L), there was a significantly greater induction of hepatic vitellogenin in DDT-exposed males in comparison to control males, indicating that exposure to estrogenic chemicals during early life stages may potentiate vitellogenin induction following exposure events later in the life of the fish.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".